Cabaletta Bio Reports Second Quarter 2020 Financial Results and Provides Business Update
“The recent initiation of patient recruitment in the DesCAARTesTM Phase 1 trial is an important milestone for Cabaletta that reflects the commitment of our outstanding team and academic partners to patients suffering with mucosal pemphigus vulgaris. This trial, evaluating the safety and tolerability of DSG3-CAART, is the first trial exploring whether a highly specific targeted cellular therapy can provide a deep and durable, perhaps curative, treatment for patients with a B cell-mediated autoimmune disease. We look forward to reporting acute safety data from the initial cohort by the first half of 2021,” said
Pipeline Highlights and Anticipated Upcoming Milestones
DSG3-CAART: Desmoglein 3 chimeric autoantibody receptor (CAAR) T cells as potential treatment for patients with mucosal pemphigus vulgaris (mPV).
- The Company’s open-label Phase 1 clinical trial (DesCAARTesTM) to evaluate the safety and tolerability of DSG3-CAART in relapsed/refractory mPV patients is now open for recruitment with clinical acute safety data from the initial cohort expected by the first half of 2021.
May 2020, the Company announced that the U.S. Food and Drug Administration(FDA) granted Fast Track Designation to DSG3-CAART, which provides independent validation of mPV as a serious and unmet medical need in patients.
MuSK-CAART: Muscle Specific Kinase (MuSK) CAAR T cells as potential treatment for MuSK-associated myasthenia gravis.
- Investigational New Drug (IND)-enabling studies are ongoing with an IND submission to the FDA anticipated in the second half of 2021.
May 2020, in vivo target engagement data was presented at the American Academy of Neurology2020 Science Highlights Virtual Platform. The data demonstrated in vitro cytotoxicity towards a B cell line expressing anti-MuSK antibodies, but no observed cytotoxicity when the anti-MuSK antibody was not expressed. MuSK CAAR T cells also targeted and eliminated a panel of B cells targeting different MuSK epitopes. In an in vivo mouse model, MuSK CAAR T cells, but not control CAAR T cells, showed biological activity by blocking the growth of B cell lines expressing an anti-MuSK antibody. This study demonstrated that MuSK CAAR T cells were able to deplete B cells expressing anti-MuSK antibodies.
- Cell processing capacity is contractually secured at the
University of Pennsylvaniafor the Phase 1 study of DSG3-CAART. Pilot partnerships with two commercial grade contract manufacturers have been initiated to support later-stage clinical development.
- Two to three years of vector supply for DSG3-CAART is secured, and pilot partnerships have been established for the production of additional vector at commercial grade and scale.
- Cabaletta expects to initiate validation of cell processing for MuSK-CAART clinical trials with a commercial grade contract manufacturing partner in the second half of 2020.
August 2020, Dr. Carl June, M.D., joined the Company’s Scientific Advisory Board. Dr. Juneled the research team that discovered and developed the first FDA-approved Chimeric Antigen Receptor (CAR) T cell therapy. He is the Richard W. Vague Professor of Immunotherapy in the Department of Pathology and Laboratory Medicineat the University of Pennsylvania, Director of the Center for Cellular Immunotherapiesat the Perelman School of Medicineand Director of the Parker Institutefor Cancer Immunotherapy at the University of Pennsylvania.
July 2020, the Company signed a gene editing research and collaboration agreement with Artisan Bio, Inc., a precision cell therapy engineering company, to accelerate development of next-generation CAAR T cell therapies with the potential for improved manufacturing and/or clinical outcomes for patients with B-cell mediated autoimmune diseases.
May 2020, the Company expanded its Sponsored Research Agreement with the University of Pennsylvania. The agreement expands the scope of sponsored research to include three additional B cell-mediated autoimmune diseases under the direction of Aimee Payne, M.D., Ph.D., a Professor of Dermatology in the Perelman School of Medicineat the University of Pennsylvania, Director of the Penn Clinical Autoimmunity Center of Excellence, and a co-founder of Cabaletta and co-chair of the Scientific Advisory Board.
Upcoming August Events
- Cabaletta will participate in a fireside chat at the
BTIG Virtual Biotechnology Conferenceon Monday, August 10, 2020at 1:00 p.m. ET.
- Cabaletta will participate in a fireside chat at the
Wedbush PacGrow Healthcare Virtual Conferenceon Tuesday, August 11, 2020at 8:35 a.m. ET.
- Cabaletta will participate in a fireside chat at the 40th Annual
Canaccord Genuity Growth Conferenceon Wednesday, August 12, 2020at 11:30 a.m. ET.
Second Quarter 2020 Financial Results
- Research and development (R&D) expenses for the three months ended June 30, 2020 were $5.3 million, compared to
$2.7 millionfor the same period in 2019.
- General and administrative (G&A) expenses for the three months ended June 30, 2020 were $2.9 million, compared to
$1.1 millionfor the same period in 2019.
- As of June 30, 2020, cash and cash equivalents and investments totaled $123.2 million, compared to
$136.2 millionas of December 31, 2019.
The Company expects that its cash and cash equivalents and investments as of
About Cabaletta Bio
This press release contains “forward-looking statements” of Cabaletta within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, but are not limited to, express or implied statements regarding Cabaletta’s beliefs and expectations regarding its: expectations of the potential impact of COVID-19 on strategy, future operations, IND submissions, contract manufacturing agreements, collaboration, and the timing of its clinical trials, as well as potential impacts on enrollment and initiation; DesCAARTesTM phase 1 clinical trial, including the expected completion of its patient recruitment, the potential timing of the initiation of patient dosing, and the results and expected timing to report clinical acute safety data from the initial cohort by the first half of 2021; MuSK-CAART program, including the completion and expected results of its ongoing IND-enabling studies and plans to submit an IND application or equivalent regulatory filing for MuSK-CAART in the second half of 2021; presentation of additional data at upcoming scientific conferences, and other preclinical data in 2020; expectations regarding the design, implementation, timing and success of its current and planned clinical trials and the successful completion of nonclinical studies; planned potential timing and advancement of its preclinical studies and clinical trials and related regulatory submissions; ability and the potential to successfully maintain or secure the necessary cell processing capacity and supply for its product candidates for clinical trials, including Cabaletta’s planned development and timing of next generation T cell engineering tools and process advancement; ability to replicate results achieved in preclinical studies or clinical trials in any future studies or trials; ability to continue its growth and realize the anticipated contribution of the members of its board of directors and executives to its operations and progress; ability to optimize the impact of its collaborations on its development programs; statements regarding the timing of regulatory filings regarding its development programs; use of capital, expenses, future accumulated deficit and other financial results in the future; and ability to fund operations through the third quarter of 2022.
Any forward-looking statements in this press release are based on management’s current expectations and beliefs of future events, and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to: risks related to the impact of COVID-19 affecting countries or regions in which we have operations or do business, including potential negative impacts on our employees, customers, supply chain and production as well as global economies and financial markets; risks related to Cabaletta’s ability to protect and maintain its intellectual property position; risks related to Cabaletta’s relationship with third parties, including its licensors and licensees; risks related to the ability of its licensors to protect and maintain their intellectual property position; uncertainties related to the initiation and conduct of studies and other development requirements for its product candidates; the risk that any one or more of Cabaletta’s product candidates will not be successfully developed and commercialized; and the risk that the results of preclinical studies or clinical studies will not be predictive of future results in connection with future studies. For a discussion of these and other risks and uncertainties, and other important factors, any of which could cause Cabaletta’s actual results to differ from those contained in the forward-looking statements, see the section entitled “Risk Factors” in Cabaletta’s most recent quarterly report on Form 10-Q as well as discussions of potential risks, uncertainties, and other important factors in Cabaletta’s other filings with the Securities and Exchange Commission. All information in this press release is as of the date of the release, and Cabaletta undertakes no duty to update this information unless required by law.
SELECTED FINANCIAL DATA
(unaudited; in thousands, except share and per share data)
Statements of Operations
|Three Months Ended
||Six Months Ended
|Research and development||$||5,331||$||2,664||$||9,951||$||5,425|
|General and administrative||2,861||1,138||6,136||2,367|
|Total operating expenses||8,192||3,802||16,087||7,792|
|Loss from operations||(8,192||)||(3,802||)||(16,087||)||(7,792||)|
|Net loss attributable to common stockholders||$||(8,152||)||$||(3,358||)||$||(15,637||)||$||(12,216||)|
|Net loss per share of voting and non-voting common stock, basic and diluted||$||(0.35||)||$||(1.87||)||$||(0.68||)||$||(7.48||)|
Selected Balance Sheet Data
|Cash, cash equivalents and investments||$||123,178||$||136,204|
|Total stockholders’ equity||124,635||138,321|
Chief Financial Officer
Stern Investor Relations, Inc.
Source: Cabaletta Bio